Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4α (HNF4α) gene
نویسندگان
چکیده
Yutaka MAEDA*1,2, Wendy W. HWANG-VERSLUES†1, Gang WEI‡3, Takuya FUKAZAWA§4, Mary L. DURBIN¶5, Laurie B. OWEN§6, Xuan LIU‡ and Frances M. SLADEK*7 *Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, U.S.A., †Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, U.S.A., ‡Department of Biochemistry, University of California, Riverside, CA 92521, U.S.A., §Department of Biomedical Sciences, University of California, Riverside, CA 92521, U.S.A., and ¶Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, U.S.A.
منابع مشابه
CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α) regulate expression of the human fructose-1,6-bisphosphatase 1 (FBP1) gene in human hepatocellular carcinoma HepG2 cells
Fructose-1,6-bisphosphatase (FBP1) plays an essential role in gluconeogenesis. Here we report that the human FBP1 gene is regulated by two liver-enriched transcription factors, CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α) in human hepatoma HepG2 cells. C/EBPα regulates transcription of FBP1 gene via binding to the two overlapping C/EBPα sites located at nuc...
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